Gene-Jack Wang, M.D.
Scientist, Medical Department of BNL
Associate Professor of Radiology, SUNY st Stony Brook.
Our studies involve using in vivo radionuclide imaging techniques
(PET and SPECT) to detect cancer (brain and breast) and substance
abuse (alcohol and cocaine). The research includes using
multi-radiotracer imaging techniques to evaluate changes in brain
dopamine system in cocaine abusers and normal aging process.
Studies also include using metabolic images to evaluate effect of
chronic alcohol abuse in alcoholics and to investigate effect of
radiotherapy to brain tumor and non-tumoral brain tissue.
We also integrate radionuclide imaging methods with other imaging
modalities such as MR imaging.
Wang G-J, Volkow ND, Roque CT, Cestaro VL, Hitzemann RJ, Cantos EL,
Levy AV, Dhawan AP: "Functional Importance of Ventricular Enlargement
and Cortical Atrophy in Healthy Subjects and Alcoholics as Assessed
with PET, MR Imaging and Neuropsychological Testing". Radiology 1993;
Wang G-J, Volkow ND, Fowler JS, Wolf AP, Ferrieri R, Schlyer DJ, Alexoff
D, Pappas N, Lieberman J, King P, Warner D, Wong C, Hitzemann RJ:
"Methylphenidate Decreases Regional Cerebral Blood Flow in the Normal
Human Subjects". Life Sciences 1994; 54:PL143-PL146.
Wang G-J, Volkow ND, Wolf AP, Brodie JD, Hitzemann RJ: "Intersubjects
Variability of Brain Glucose Metabolic Measurements in Young Normal
Males". Journal of Nuclear Medicine 1994; 35:1457-1466.
Wang G-J, Volkow ND, Fowler JS, Logan J, Schlyer DJ, Hitzemann RJ, Gur
R, Wolf AP: "Evaluation of Age-Related Changes in Serotonin 5-HT2 and
Dopamine D2 Receptor Availability in Healthy Human Subjects". Life
Sciences 1995; 56:PL249-253.
Wang G-J, Volkow ND, Levy A, Fowler JS, Alexoff D, Schlyer DJ,
Hitzemann RJ, Wolf AP: "MR-PET Images Coregistration for Quantification
of Dopamine D2 Receptors". Journal of Computer Assisted Tomography;
Wang G-J, Volkow ND, Hitzemann RJ, Pappas N, Pascarni K, Fowler JS:
"Reproducibility of Regional Brain Metabolic Responses to Lorazepam".
Journal of Nuclear Medicine; In press.
Wang G-J, Volkow ND, Lau YH, Fowler JS, Meek A, Park T, Wong C, Roque
CT, Adler A, Wolf AP: "Glucose Metabolism in Brain Tumors and in
Non-Tumoral Brain Tissue in Patients Scanned Before and after
Radiotherapy". Journal of Computer Assisted Tomography; In press.
Brookhaven National Laboratory
Upton, NY 11973
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