Gene-Jack Wang, M.D.

Scientist, Medical Department of BNL
Associate Professor of Radiology, SUNY st Stony Brook.

Research Interest:

Our studies involve using in vivo radionuclide imaging techniques (PET and SPECT) to detect cancer (brain and breast) and substance abuse (alcohol and cocaine). The research includes using multi-radiotracer imaging techniques to evaluate changes in brain dopamine system in cocaine abusers and normal aging process. Studies also include using metabolic images to evaluate effect of chronic alcohol abuse in alcoholics and to investigate effect of radiotherapy to brain tumor and non-tumoral brain tissue. We also integrate radionuclide imaging methods with other imaging modalities such as MR imaging.

Selected Publications:

Wang G-J, Volkow ND, Roque CT, Cestaro VL, Hitzemann RJ, Cantos EL, Levy AV, Dhawan AP: "Functional Importance of Ventricular Enlargement and Cortical Atrophy in Healthy Subjects and Alcoholics as Assessed with PET, MR Imaging and Neuropsychological Testing". Radiology 1993; 186: 59-65.

Wang G-J, Volkow ND, Fowler JS, Wolf AP, Ferrieri R, Schlyer DJ, Alexoff D, Pappas N, Lieberman J, King P, Warner D, Wong C, Hitzemann RJ: "Methylphenidate Decreases Regional Cerebral Blood Flow in the Normal Human Subjects". Life Sciences 1994; 54:PL143-PL146.

Wang G-J, Volkow ND, Wolf AP, Brodie JD, Hitzemann RJ: "Intersubjects Variability of Brain Glucose Metabolic Measurements in Young Normal Males". Journal of Nuclear Medicine 1994; 35:1457-1466.

Wang G-J, Volkow ND, Fowler JS, Logan J, Schlyer DJ, Hitzemann RJ, Gur R, Wolf AP: "Evaluation of Age-Related Changes in Serotonin 5-HT2 and Dopamine D2 Receptor Availability in Healthy Human Subjects". Life Sciences 1995; 56:PL249-253.

Wang G-J, Volkow ND, Levy A, Fowler JS, Alexoff D, Schlyer DJ, Hitzemann RJ, Wolf AP: "MR-PET Images Coregistration for Quantification of Dopamine D2 Receptors". Journal of Computer Assisted Tomography; In press.

Wang G-J, Volkow ND, Hitzemann RJ, Pappas N, Pascarni K, Fowler JS: "Reproducibility of Regional Brain Metabolic Responses to Lorazepam". Journal of Nuclear Medicine; In press.

Wang G-J, Volkow ND, Lau YH, Fowler JS, Meek A, Park T, Wong C, Roque CT, Adler A, Wolf AP: "Glucose Metabolism in Brain Tumors and in Non-Tumoral Brain Tissue in Patients Scanned Before and after Radiotherapy". Journal of Computer Assisted Tomography; In press.

Medical Department
Brookhaven National Laboratory
Upton,  NY 11973
Phone: 516-344-3608
Fax: 516-344-5311

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